In this week's episode, Blood editor Dr. Natalie Rosen interviews Dr. Lindsey George, Director of Clinical In Vivo Gene Therapy and an attending physician in the Division of Hematology at Children's Hospital of Philadelphia, and also Dr. Miles Horton and Dr. Thomas Lew of the Royal Melbourne Hospital and Peter McCallum Cancer Center, and the Walter and Eliza Hall Institute of Medical Research on their latest articles published in Blood on the characterization of the prothrombotic mechanisms of recombinant FVIII Aurora and turning immunosuppressants into tools for bidirectional in vivo control. Dr. George discusses "Factor VIII Aurora: a naturally occurring gain-of-function FVIII variant with enhanced FIXa affinity" and Drs. Horton and Lew discuss "Prime editing enables drug-controllable T-cell therapies with clinical immunosuppression".